Since The Big Bang Theory was on the air for 12 seasons, the main cast members worked with a huge number of guest stars. Actors have mixed thoughts about their time on the overwhelmingly popular sitcom. Some celebrities like Charlie Sheen didn't like appearing on TBBT. Other actors sounded excited about the opportunity.

While it's fun to hear what guest stars thought about The Big Bang Theory, it's also cool to hear the main cast's perspective. Jim Parsons and Mayim Bialik, who played the sweet and smart couple Sheldon Cooper and Amy Farrah Fowler, explained during a Comic-Con interview that there was one guest actor who made a scene pretty difficult to film.

Here's what happened...

What Did Jim Parsons And Mayim Bialik Say About A Guest Star On The Big Bang Theory?

Whether fans love attending Comic-Con in person or are happy to watch YouTube footage of certain panels afterward, there's no question that this fun event can lead to a lot of juicy reveals. Often, when the cast of a popular TV series sits on a panel and answers questions, they end up sharing some hilarious or memorable experiences that people wouldn't hear about otherwise.

When The Big Bang Theory cast spoke at a Comic-Con panel in July 2011, Jim Parsons talked about a filming experience that sounded tricky.

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